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Activated Protein C Resistance

What is the Activated Protein C Resistance (APC-R) Test?
The Activated Protein C Resistance (APC-R) test is used to detect resistance to activated protein C, a vital protein involved in regulating blood clotting. APC resistance is one of the most common inherited causes of abnormal blood clot formation and is strongly linked to an increased risk of deep vein thrombosis (DVT) and pulmonary embolism.

Why APC-R Testing is Important
APC resistance is most frequently caused by a genetic mutation known as Factor V Leiden. This mutation interferes with the body’s natural anticoagulant response, making individuals more prone to developing blood clots. Early identification allows for effective prevention and management of thrombotic events, particularly in individuals with a history of clotting disorders.

When is the APC-R Test Recommended?
Healthcare providers may recommend APC-R testing for individuals with:

A personal or family history of blood clots (thrombosis)

Recurrent unexplained miscarriages

Prolonged immobilisation or recent major surgery

High-risk cardiovascular factors such as smoking, obesity, or long-term oral contraceptive use

What the APC-R Test Can Detect
The APC-R test primarily identifies the presence of the Factor V Leiden mutation, the most common genetic cause of APC resistance. Detecting this mutation allows for targeted lifestyle adjustments, preventive treatments, and regular monitoring to reduce the risk of future clotting events.

Fasting and Test Preparation
No fasting is required before taking the APC-R test. Patients may continue with their usual diet and medications unless advised otherwise by their doctor.

Private APC-R Blood Testing in Slough and Surrounding Areas
Specialist APC-R testing, including Factor V Leiden detection, is available in Slough, Windsor, Maidenhead, and surrounding Berkshire areas. This test plays a critical role in identifying clotting risk, especially for individuals with a personal or family history of thrombosis, ensuring early intervention and tailored care.