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Activated Protein C Resistance

The activated protein C resistance (APC-R) test helps identify resistance to activated protein C (APC), a crucial protein in controlling blood clotting. APC resistance is a leading cause of inherited blood clotting disorders and can increase the risk of developing conditions like deep vein thrombosis (DVT) and pulmonary embolism. Why is this test important? APC resistance, often due to a genetic mutation known as Factor V Leiden, disrupts the body’s ability to regulate blood clotting efficiently. Identifying this resistance allows for better prevention and management of thrombotic events, especially in individuals with a family history of blood clotting disorders or unexplained clotting episodes. When is the APC-R test recommended? Doctors may recommend the APC-R test if you have: - A personal or family history of thrombosis (blood clots). - Unexplained recurrent miscarriages. - Prolonged immobilization or surgery that increases clotting risk. - High-risk factors for cardiovascular disease, such as smoking, obesity, or long-term oral contraceptive use. What can the APC-R test detect? This test primarily detects Factor V Leiden mutation, the most common cause of APC resistance. Early detection aids in implementing lifestyle modifications, preventive treatments, and ongoing monitoring to reduce clotting risks. Fasting requirements No fasting is required for the APC-R test. You may continue with your usual diet and medications unless instructed otherwise by your healthcare provider.

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