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Anti-Glycoprotein-210 Antibodies (AGPA)

Overview of Pernicious Anaemia

Pernicious anaemia is a chronic autoimmune disorder that leads to vitamin B12 deficiency. It is characterised by the presence of autoantibodies that target the stomach's parietal cells, the proton pump, and intrinsic factor – a protein essential for vitamin B12 absorption.

Autoantibodies Involved in Pernicious Anaemia

In individuals with pernicious anaemia, the immune system produces:

Anti-gastric parietal cell antibodies (AGPA)

Intrinsic factor antibodies
These autoantibodies interfere with the normal absorption of cobalamin (vitamin B12), leading to deficiency and related symptoms.

Diagnostic Tests for Pernicious Anaemia

To accurately diagnose pernicious anaemia and determine the underlying cause of vitamin B12 deficiency, the following tests are commonly used:

Anti-parietal cell and intrinsic factor antibody testing

Vitamin B12 blood levels

Methylmalonic acid test

Complete blood count (CBC)

Blood film examination

These diagnostic measures help evaluate the severity of deficiency and rule out other potential causes.

Private Blood Testing for Pernicious Anaemia in Slough

Residents of Slough, Langley, Windsor, and Maidenhead can access private diagnostic services for pernicious anaemia and vitamin B12 deficiency. Early detection through autoimmune antibody testing and blood profiling enables effective treatment planning and symptom management.

There is an additional £25 phlebotomy fee for every donation.