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Down Syndrome: PAPP-A Test (10-14 Week, 1st Trimester, NT)

What Is Pregnancy-Associated Plasma Protein A (PAPP-A)?

Pregnancy-associated plasma protein A (PAPP-A) is a protein produced by the outer layer of the developing placenta during early pregnancy. It plays a key role in regulating the growth and development of the fetus.

Importance of Nuchal Translucency Measurement

Nuchal translucency is a measurement taken during an early pregnancy ultrasound scan. It assesses the fluid-filled space at the back of the fetal neck and is used as a marker for chromosomal abnormalities.

Combined Screening for Trisomy 21 (Down’s Syndrome)

When PAPP-A and nuchal translucency results are combined with beta-human chorionic gonadotropin (β-hCG) levels, they provide a calculated risk assessment for chromosomal conditions such as Trisomy 21, commonly known as Down’s syndrome. This combined first-trimester screening helps in the early detection of potential genetic abnormalities.

Specialist PAPP-A Testing in Slough and Surrounding Areas

Pregnancy screening, including PAPP-A testing and nuchal translucency assessment, is available for individuals in Slough, Windsor, Langley, Maidenhead, and nearby locations. This is a specialist test—please contact the laboratory directly for full instructions and to arrange an appointment. Early screening in Slough supports informed prenatal care and reassurance for expectant parents.

There is an additional £20 phlebotomy fee for every donation.