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Endomysial IgA

What Is Endomysial IgA?

Endomysial IgA refers to the presence of immunoglobulin A (IgA) antibodies targeting the endomysium, a layer of connective tissue surrounding muscle fibres. These antibodies are detectable in the bloodstream and serve as a key marker in the diagnosis of autoimmune conditions, particularly celiac disease.

Role in Diagnosing Celiac Disease

Endomysial IgA testing is primarily used to support the diagnosis of celiac disease—an autoimmune disorder triggered by the ingestion of gluten in genetically predisposed individuals. Gluten is a protein found in wheat, rye, and barley.

Endomysial Antibodies and Immune Response

In individuals with celiac disease, the immune system mistakenly reacts to gluten by producing endomysial antibodies, which then attack the body’s own tissues. This immune response can lead to inflammation and damage of the small intestine lining, impairing nutrient absorption and causing both digestive and non-digestive symptoms.

Accuracy and Specificity

Endomysial IgA is considered one of the most specific markers for celiac disease and is found in over 90% of individuals with the condition. Its high specificity makes it a valuable diagnostic tool, especially when used alongside other tests.

Combined Testing for Celiac Disease

Endomysial IgA testing is typically performed in conjunction with:

Tissue Transglutaminase (tTG) IgA

Gliadin IgA Antibodies

This combination improves diagnostic accuracy and is also helpful in monitoring treatment progress in patients following a gluten-free diet.

Endomysial IgA Testing in Slough and Surrounding Areas

Private blood testing for Endomysial IgA is available in Slough, Windsor, Langley, Maidenhead, and surrounding Berkshire areas. If you experience symptoms such as bloating, fatigue, unexplained weight loss, or digestive issues linked to gluten, celiac testing services in Slough can help confirm a diagnosis and guide effective treatment through dietary management.

There is an additional £20 phlebotomy fee for every donation.