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Prostate-Specific Antigen Free (fPSA)

PSA is organ specific, being produced primarily by prostatic secretory epithelium, but has long been known to be elevated in non‑malignant conditions such as benign prostatic hyperplasia (BPH). A number of studies have found that the % free PSA was significantly lower in patients having prostate cancer than those with benign disease or normal controls. The ratio fPSA/tPSA has been demonstrated to improve the sensitivity and specificity in patients with tPSA values in the “gray zone” of 4‑10 ng/mL.

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