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Waaler-Rose

Waaler-Rose Test for Rheumatoid Factor Detection in Slough

What is the Waaler-Rose Test?
The Waaler-Rose test is a historical blood test used to detect the presence of rheumatoid factor (RF)—an antibody commonly found in individuals with rheumatoid arthritis (RA). Developed in the 1940s by Norwegian physicians Jan Waaler and Niels Christian Rose, the test contributed significantly to the early diagnosis and research of autoimmune joint diseases.

How the Waaler-Rose Test Works
The test involves mixing a patient’s blood serum with sheep red blood cells that are coated with rabbit anti-sheep antibodies. If RF is present in the serum, it binds to the coated cells, causing visible agglutination (clumping). The degree of clumping is measured and graded to estimate the level of rheumatoid factor in the blood.

Clinical Use and Evolution of Testing
Although the Waaler-Rose test was groundbreaking for its time, it has largely been replaced by more modern methods due to its limited sensitivity and specificity. Current RF tests used in diagnostic clinics across Slough and surrounding areas include:

Latex agglutination test

Enzyme-linked immunosorbent assay (ELISA)

These newer tests offer greater accuracy, can detect lower concentrations of RF, and are more reliable for early-stage rheumatoid arthritis and other autoimmune conditions.

Why Test for Rheumatoid Factor in Slough?
RF testing remains a critical component in diagnosing autoimmune conditions. Residents in Slough, Windsor, Langley, and Maidenhead may undergo RF testing as part of investigations into symptoms such as:

Persistent joint pain or swelling

Stiffness, especially in the morning

Signs of systemic inflammation

Suspected autoimmune or connective tissue disorders

Conditions Detected by RF Testing

Rheumatoid arthritis

Sjogren’s syndrome

Chronic infections or other autoimmune diseases

Book Modern RF Testing in Slough Today
While the Waaler-Rose test is no longer widely used, it laid the foundation for the advanced RF testing now available in private clinics across Slough. Schedule your rheumatoid factor test today to support early diagnosis and effective treatment planning for autoimmune and inflammatory joint conditions.

There is an additional £20 phlebotomy fee for every donation.