Zonulin LIS Code: Zonulin
Measure zonulin levels to assess gut permeability and digestive health. Private testing with fast results available across the UK.
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About this test
Overview of the Zonulin Test
The zonulin test is designed to measure the levels of zonulin—a protein responsible for regulating the permeability of the intestinal lining. This protein plays a crucial role in maintaining the gut barrier, determining what passes from the intestines into the bloodstream. Elevated zonulin levels may indicate increased intestinal permeability, often referred to as “leaky gut,” which is associated with a range of health concerns.
Why Zonulin Matters
Zonulin controls the tight junctions between intestinal cells, ensuring that only essential nutrients are absorbed while preventing harmful substances from entering the bloodstream. When zonulin levels rise, these junctions may loosen, compromising the gut barrier. This allows toxins, pathogens, and undigested food particles to enter circulation, potentially triggering immune responses, chronic inflammation, and various health conditions.
When to Consider Testing
Ongoing digestive issues such as bloating, abdominal pain, or diarrhea
Diagnosis or monitoring of autoimmune diseases like celiac disease or Crohn’s disease
Food intolerances or unexplained allergic reactions
Signs of chronic inflammation or persistent fatigue
Suspected cases of leaky gut syndrome
Gut health evaluation in individuals with IBS or metabolic syndrome
Preparation for the Test
Generally, no special preparation is needed before taking a zonulin test.
