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GAD Ab

What is GAD Ab (Glutamic Acid Decarboxylase Antibody)

GAD Ab refers to antibodies directed against glutamic acid decarboxylase (GAD), an enzyme involved in the production of gamma-aminobutyric acid (GABA), a key neurotransmitter that regulates neuronal excitability in the central nervous system.

Function of GAD

GAD plays a critical role in synthesizing GABA, which helps maintain balance in nerve signaling and prevents overstimulation of the nervous system.

Role of GAD Antibodies

GAD antibodies are autoantibodies produced by the immune system that mistakenly target the GAD enzyme.

Clinical Significance of Elevated GAD Ab Levels

High levels of GAD antibodies are commonly associated with autoimmune conditions such as:

Type 1 diabetes

Stiff person syndrome

Certain types of epilepsy

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