Rheumatoid Profile II LIS Code: RHEUMATOID II
Comprehensive rheumatoid profile for detecting autoimmune and inflammatory conditions like rheumatoid arthritis and lupus. Includes RF, Anti-CCP, ANA, CRP, and complement tests.
What's included in this profile
- One of three antibody types tested for antiphospholipid syndrome
- Linked to increased risk of blood clots and pregnancy complications
- Usually tested together with IgG and IgM forms
- One of three antibody types tested for antiphospholipid syndrome
- Linked to increased risk of blood clots and pregnancy complications
- Usually tested together with IgA and IgM forms
- One of three antibody types tested for antiphospholipid syndrome
- Linked to increased risk of blood clots and pregnancy complications
- Usually tested together with IgA and IgG forms
- A screening test for autoimmune conditions
- A positive result prompts further specific antibody testing
- Can also be positive in some healthy people, so interpreted with symptoms
- A protein that rises quickly in response to inflammation or infection
- A general marker, not specific to any one condition
- Useful for tracking how the body is responding over time
- An antibody linked to a form of scleroderma
- Usually checked after a positive ANA result
- Helps identify specific autoimmune connective tissue disease
- A protein of the complement immune system
- Levels can be low in certain active autoimmune conditions
- Often checked alongside C4 and ANA testing
- A protein of the complement immune system
- Levels can be low in certain active autoimmune conditions
- Often checked alongside C3 and ANA testing
- An antibody strongly associated with lupus (SLE)
- Usually checked after a positive ANA result
- Levels can also help track disease activity
- An older, general marker of inflammation in the body
- Measures how quickly red blood cells settle in a test tube
- Often used alongside CRP for a fuller inflammation picture
- A panel of antibodies linked to various autoimmune conditions
- Usually checked after a positive ANA result
- Helps identify which specific autoimmune condition may be present
- Measures red cells, white cells and platelets
- A foundational test for overall health, anaemia and infection
- The 'Differential' breaks white cells down by specific type
- An antibody that can be linked to druginduced lupus
- Usually checked after a positive ANA result
- Helps clarify the type of autoimmune reaction present
- An antibody linked to certain inflammatory muscle conditions
- Usually checked as part of a wider autoimmune antibody panel
- Helps identify specific autoimmune conditions
- An antibody linked to certain autoimmune connective tissue diseases
- Usually checked as part of the ENA antibody panel
- Helps refine autoimmune diagnosis
- An antibody associated with rheumatoid arthritis
- Can also be positive in other autoimmune or chronic conditions
- Interpreted alongside symptoms and other antibody tests
- An antibody linked to Sjögren's syndrome and lupus
- Usually checked as part of the ENA antibody panel
- Helps identify specific autoimmune conditions
- An antibody linked to Sjögren's syndrome and lupus
- Usually checked as part of the ENA antibody panel
- Often checked alongside SSA (Ro) antibody
- An antibody highly specific to lupus (SLE)
- Usually checked as part of the ENA antibody panel
- A positive result is strongly suggestive of lupus
- A waste product from the breakdown of purines in food and cells
- Raised levels are linked to gout and kidney stones
- Also checked as part of general metabolic screening
About this profile
The Rheumatoid Profile II is a comprehensive blood test that provides an in-depth evaluation of key markers linked to autoimmune and inflammatory disorders, including rheumatoid arthritis and systemic lupus erythematosus (SLE). This advanced profile helps identify immune system dysfunction, assess inflammation, and support accurate diagnosis and ongoing monitoring of complex autoimmune conditions.
Who is this profile for?
This test is ideal for individuals experiencing persistent joint pain, stiffness, swelling, fatigue, or unexplained inflammation. It is also beneficial for patients with suspected or confirmed autoimmune disorders who require a detailed analysis to guide disease management, monitor treatment effectiveness, or assess disease progression.
What can be detected?
The Rheumatoid Profile II measures a wide range of markers that provide valuable insights into autoimmune and inflammatory health:
Full Blood Count (FBC) + Differential: Evaluates blood cell levels to detect anemia, infection, or inflammation.
Erythrocyte Sedimentation Rate (ESR): Indicates the presence and severity of inflammation in the body.
C-Reactive Protein (CRP): Measures active inflammation and helps monitor response to treatment.
Rheumatoid Factor (RF) Quantitative: Detects antibodies associated with rheumatoid arthritis and related autoimmune disorders.
Anti-Cyclic Citrullinated Peptide (Anti-CCP): A highly specific marker for rheumatoid arthritis, often used to confirm diagnosis.
Antinuclear Antibodies (ANA): Detects autoantibodies commonly present in autoimmune diseases like lupus and mixed connective tissue disorders.
Complement C3 and C4: Measures complement protein levels that play a role in immune system activation and inflammation; reduced levels may indicate autoimmune disease activity.
Uric Acid: Assesses levels linked to gout or inflammation-related joint pain.
When to get tested
This profile is recommended for individuals with symptoms consistent with autoimmune or inflammatory diseases, including chronic joint pain, fatigue, or skin rashes. It is also suitable for patients under treatment for rheumatoid arthritis, lupus, or other autoimmune conditions who require ongoing disease monitoring.
Fasting requirements
Fasting is not required for this test. However, patients should follow any specific guidelines provided by their healthcare provider for optimal accuracy.
Key benefits
The Rheumatoid Profile II delivers a detailed analysis of inflammatory and autoimmune markers, helping clinicians differentiate between related conditions, monitor disease activity, and personalize treatment plans. This comprehensive evaluation supports early diagnosis, improved disease management, and better long-term outcomes for patients with autoimmune or inflammatory disorders.
