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C1 Esterase Inhibitor

What Is C1 Esterase Inhibitor (C1-INH)?

C1 esterase inhibitor (C1-INH) is a vital protein that helps regulate the complement and kinin systems—two key components of the body’s immune and inflammatory responses. The complement system targets and destroys harmful pathogens like bacteria and viruses, while the kinin system manages inflammation and blood pressure.

Function of C1-INH in Immune Regulation

C1-INH controls the activation of these immune pathways, preventing excessive responses that could lead to tissue damage and inflammation. Proper regulation of C1-INH is essential for maintaining immune balance and protecting healthy tissues.

What Does the C1-INH Blood Test Measure?

The C1-INH test evaluates both the quantity and functional activity of C1 esterase inhibitor in the blood. It helps detect abnormalities in the immune system and is a key diagnostic tool in identifying certain rare disorders.

Conditions Associated with Abnormal C1-INH Levels

Low C1-INH Levels:

Hereditary Angioedema (HAE): A rare genetic disorder characterised by repeated episodes of swelling in the face, throat, abdomen, or limbs.

Acquired Angioedema (AAE): Caused by autoimmune reactions or as a side effect of certain medications.

High C1-INH Levels:

May be seen in inflammatory or autoimmune conditions such as:

Systemic lupus erythematosus (SLE)

Rheumatoid arthritis

Can serve as an indicator of ongoing immune system activity or disease progression.

When Is C1-INH Testing Recommended?

Recurrent or unexplained episodes of swelling

Suspected hereditary or acquired angioedema

Autoimmune disease monitoring

Investigation of immune system dysfunction

C1-INH Blood Testing in Slough and Surrounding Areas

Private C1 esterase inhibitor testing is available in Slough, Windsor, Langley, Maidenhead, and surrounding Berkshire locations. If you’re experiencing recurrent swelling, unexplained allergic reactions, or symptoms of autoimmune conditions, local diagnostic services in Slough offer reliable C1-INH testing to support accurate diagnosis and appropriate treatment planning.

There is an additional £20 phlebotomy fee for every donation.