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Lipoprotein (a)

Lipoprotein (a) (Lp(a)) is composed of an LDL‑like particle to which the lipoprotein (a)‑specific apolipoprotein (a) is bonded by a disulfide bridge. Apolipoprotein (a) is highly homologous to plasminogen. Lipoprotein (a) is a cholesterol‑rich lipoprotein which is synthesized in the liver independently of triglycerides and is not subject to the influence of age or diet. Several unrelated studies showed that Lp(a) is an independent prospective risk factor for coronary heart disease.

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