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TSH Receptor Antibodies (TRAb)

TSH receptor antibodies are antibodies that develop when a person's immune system mistakenly targets the thyroid gland or thyroid proteins, leading to chronic inflammation of the thyroid (thyroiditis), tissue damage, and/or disruption of thyroid function. They are heterogeneous and may either mimic the action of TSH and cause hyperthyroidism or alternatively, antagonize the action of TSH and cause hypothyroidism.

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