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Antineutrophil Cytoplasmic Antibodies: Cytoplasmic Staining (ANCA-C)

Understanding Antineutrophil Cytoplasmic Antibodies (ANCA)

Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies that target specific proteins within white blood cells, playing a critical role in the immune response. These antibodies are classified into two patterns based on laboratory staining techniques: cANCA (cytoplasmic) and pANCA (perinuclear).

Diagnostic Importance of ANCA Testing

ANCA testing is essential for diagnosing certain autoimmune vasculitic disorders. These conditions involve inflammation of the blood vessels and can affect multiple organ systems, making early diagnosis crucial for effective treatment.

Conditions Diagnosed with ANCA

The presence of cANCA and pANCA is closely associated with:

Wegener’s granulomatosis (now known as granulomatosis with polyangiitis, GPA)

Microscopic polyangiitis (MPA)

Pauci-immune necrotizing glomerulonephritis

Other organ-specific vasculitic variants

These disorders often present with symptoms involving the kidneys, respiratory tract, and generalised systemic inflammation.

When to Consider ANCA Testing

ANCA blood testing is typically recommended for individuals experiencing:

Persistent sinus or lung infections

Unexplained kidney issues

Fatigue, joint pain, or systemic inflammation

Suspected autoimmune vasculitis

ANCA Blood Test in Slough and Surrounding Areas

If you’re located in Slough, Windsor, Langley, Maidenhead, or surrounding areas in Berkshire and are experiencing symptoms linked to autoimmune conditions, private ANCA blood testing is available. These specialised tests help in the early detection and accurate diagnosis of autoimmune vasculitis, ensuring timely and effective clinical management.

There is an additional £20 phlebotomy fee for every donation.