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Sex Hormone Binding Globulin (SHBG)

What is Sex Hormone-Binding Globulin (SHBG)?

Sex hormone-binding globulin (SHBG) is a key transport protein found in the bloodstream. It binds reversibly to sex steroids such as testosterone and oestrogen, helping to regulate their bioavailability in the body. Although albumin is more abundant in blood than SHBG, it binds to sex hormones with significantly lower affinity.

SHBG’s Role in Hormone Regulation

SHBG controls how much free, active hormone is available to tissues. By binding to androgens and oestrogens, it plays a major role in maintaining hormonal balance. When SHBG levels are abnormal, it can affect the amount of free testosterone or oestradiol circulating in the body, even if total hormone levels appear normal.

Why Measure SHBG Levels?

Measuring SHBG is particularly useful in cases where symptoms of excess androgen activity are present, but total androgen levels (like testosterone) are within the normal range. This may indicate chronic or excessive androgenic action not immediately evident through standard testosterone testing alone.

SHBG as a Supplementary Diagnostic Tool

SHBG testing serves as a valuable supplementary marker when:

A relatively high concentration of free testosterone is suspected

There is a mismatch between hormone levels and clinical symptoms

Conditions such as polycystic ovary syndrome (PCOS) or androgenic alopecia are being investigated

SHBG Testing in Slough for Hormonal Imbalance

For individuals in Slough and surrounding areas experiencing symptoms of hormonal imbalance, SHBG testing provides deeper insight into androgen activity and hormone transport. Local hormone testing services in Slough offer advanced diagnostics to guide personalised treatment plans for both men and women.