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Y Chromosome Microdeletions

What Are Y Chromosome Microdeletions

Y chromosome microdeletions are genetic abnormalities involving the loss of small segments of genetic material from the Y chromosome in males.

Role of the Y Chromosome

The Y chromosome is one of the two sex chromosomes and contains essential genes related to male development and fertility.

Impact on Fertility

Microdeletions in the Y chromosome can disrupt genes critical for sperm production, leading to infertility and other reproductive issues.

AZF Regions and Sperm Development

The most commonly affected areas are the azoospermia factor (AZF) regions, which play a vital role in the development and maturation of sperm cells.

Testing for Y Chromosome Microdeletions

This test involves DNA analysis to detect the presence or absence of genetic material in the AZF regions. It is typically recommended for men experiencing infertility or low sperm count, as Y chromosome microdeletions are a frequent cause of male infertility.

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