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Growth Hormone (HGH)

Role of Growth Hormone and IGFs in Human Growth

Human growth is regulated by the anabolic and mitogenic effects of growth hormone (GH) and insulin-like growth factors (IGFs). Growth hormone promotes a range of physiological processes including increased glucose uptake, protein synthesis, and fat breakdown (lipolysis), with its primary role being the stimulation of bone elongation, particularly during childhood and adolescence.

Growth Hormone Excess: Gigantism and Acromegaly

An excess of growth hormone can result in distinct disorders depending on the stage of life:

Gigantism: Occurs in children and adolescents before the closure of epiphyseal growth plates, leading to abnormally tall stature due to excessive GH and IGF-1 activity.

Acromegaly: Develops in adults after growth plate fusion. It is characterised by enlarged hands and feet, coarsened facial features, and can lead to serious complications including cardiovascular, respiratory, and metabolic disorders, increasing the risk of long-term health issues.

Growth Hormone Deficiency and Its Impact

Growth hormone deficiency (GHD) presents differently in children and adults:

In children, GHD leads to delayed linear growth relative to bone age, affecting overall height and development.

In adults, severe GHD is associated with reduced muscle strength, low bone density, increased abdominal fat, and heightened cardiovascular risk due to factors such as impaired insulin sensitivity and abnormal cholesterol levels.

GH and IGF Testing in Slough

For individuals in Slough and surrounding Berkshire areas experiencing symptoms of abnormal growth, hormonal imbalance, or metabolic issues, growth hormone and IGF-1 testing offers essential insights. Local diagnostic clinics in Slough provide comprehensive endocrine assessments to support early detection, diagnosis, and personalised treatment for conditions like gigantism, acromegaly, and GH deficiency.