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Thyroglobulin Antibodies (TG Ab)

Thyroglobulin (Tg) is produced in the thyroid gland and is a main component in the lumen of the thyroid follicle. Elevated serum concentrations of antibodies against Tg (Tg‑autoantibodies) are found in subjects with autoimmunity‑based thyroiditis. High concentrations of anti‑Tg together with anti‑TPO are indicative of chronic lymphocytic‑infiltrative thyroiditis (Hashimoto's disease). The frequency of thyroglobulin antibodies is approx. 70‑80 % in subjects with autoimmune‑thyroiditis, including Hashimoto's disease, and approx. 30 % in individuals with Graves' disease.

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